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Effect of varying surface patterns on antibiotic elution from antibiotic-loaded bone cement In an effort to improve the antibiotic elution characteristics of the prosthesis of antibiotic-loaded acrylic cement, an in vitro study was conducted. Tobramycin-loaded bone cement blocks of three different surface patterns with different surface area-to-volume ratios were used. The elution of tobramycin over a 2-month period was investigated. There was a gradual decline in the tobramycin elution rate over time. The surface pattern with the increased surface area-to-volume ratio showed a significant increase in the tobramycin elution rate over the first week of the study. The surface pattern with ridges but no change in the surface area-to-volume ratio did not result in a statistically significant increase in the tobramycin elution rate.,Peer reviewed,Published. 1995 UUID:  e692d8a1-776f-424c-abeb-1dbb5a394cc5 English Paris, Nancy Masri, Bassam A. Duncan, Clive P. Beauchamp, Christopher, R. Arntorp, Jennifer Elsevier Inc. Text © 1995 Churchill Livingstone Inc. Antibiotic Elution Cement Arthroplasty Infection