Abstract
The oligosaccharide β-d-Galf-(1â†'3)-α-d-Manp-(1â†'2)-[β-d-Galf-(1â†'3)]-α-d-Manp-(1â†'2)-α-d-Manp corresponds to the terminal end of the glycosylinositolphospholipid oligosaccharide of the protozoan Trypanosomacruzi, the causative agent of Chagas’ disease. Syntheses of methyl or ethylthio glycosides of the terminal disaccharide, trisaccharide, tetrasaccharide, and pentasaccharide corresponding to this structure are described. These syntheses employ the selective activation of a phenyl 1-selenogalactofuranoside or a phenyl 1-selenomannopyranoside donor over ethyl 1-thioglycoside acceptors with NISâ€"TfOH.,Peer reviewed,Published. Received 8 December 1999; Accepted 14 December 1999; Available online 19 April 2000.